Reflections & Innovations in Clinical Pharmacology: 50 Years of the BJCP



To celebrate its 50th year of publication, the British Journal of Clinical Pharmacology (BJCP) brings together international speakers to look at the past, present and future of clinical pharmacology.


To celebrate its 50th year of publication, the British Journal of Clinical Pharmacology (BJCP) invites you to a special afternoon event at the John Vane Science Centre to celebrate the past, present and future of clinical pharmacology.

Join us to raise a glass and hear international speakers discuss a range of topics including clinical pharmacology post-WWII, the impact of the BJCP, toxicology, global outreach, patient advocacy, personalised medicine, clinical drug development and more!

There will also be a National Clinical Pharmacology Training session from 9.00am - 12.00pm for Specialty Registrars (StRs) which will be led by some of the speakers. If you are interested in attending the StR training session, please contact clinical@bps.ac.uk for more information.

 
12:00 – 13:00 Registration and refreshments 
 
13:00 – 14:45   
 
Session One: History of BJCP
Session Chairs: Professor Robin Ferner, Professor Robert Flanagan and Professor Robert Bies 

 
13:00 – 13:05 Welcome & introduction: Professor Sir Mark Caulfield
 
13:05 – 13:35 Professor Tilli Tansey
Clinical Pharmacology post second world war

 
13:35 – 14:15 Professor Geoffrey Tucker, Dr Jeffrey Aronson, Professor James Ritter and Professor Adam Cohen
History of BJCP

 
14:15 – 14:30 Professor Serge Cremers, Dr Andrew Webb and Professor Robert Likic
Present day and future of BJCP

 
14:30 – 14:45 Professor James Dear
BJCP and Toxicology

 
14:45 – 15:15 Refreshment break
 
15:15 – 17:00 Session Two: History In The Making
Session Chairs: Professor Reecha Sofat, Dr Emma Magavern and Dr James Fullerton

 
15:15 – 15:35 Professor Michael Rieder and Professor Catriona Waitt
BJCP and Global Outreach

 
15:35 – 15:55 Generation R
BJCP and Patient Advocacy

 
15:55 – 16:15 Professor Ann Daly
BJCP and Personalised Medicine

 
16:15 – 16:35 Professor Oscar Della Pasqua, Dr Daniel Marks and Professor Geert Jan Groeneveld 
BJCP and Clinical Drug Development

 
16:35 – 17:00 Dame June Raine
MHRA and Clinical Pharmacology

 
17:00 – 17:05 Professor Sir Munir Pirmohamed
Closing remarks

 

Professor Tilli Tansey, OBE, FMedSci



Speaker: Professor Tilli Tansey, Emeritus Professor of Medical History & Pharmacology, William Harvey Research Institute, Barts&The London School of Medicine and Dentistry, QMUL;  
Honorary Professor, Department of Neuroscience, Physiology & Pharmacology, UCL

Talk title: Clinical Pharmacology post second world war

Biography: After receiving her  PhD (on catecholamines in Octopus brain),  Tilli  spent several years as a research neuroscientist.  In 1990 she achieved a PhD in medical history and was a staff member of the Wellcome Trust and later UCL, becoming Professor of the History of Modern Medical Sciences there before joining QMUL. She is now Emeritus Professor of Medical History & Pharmacology at the William Harvey Research Institute, QMUL, and Honorary Professor in the Department of Neuroscience, Physiology and Pharmacology, UCL. 

She is a  Fellow of the Academy of Medical Sciences, and an Honorary Fellow of the Royal College of Physicians of London,  the Royal Society of Medicine,  the Physiological Society and the Worshipful Society of Apothecaries. She is an Honorary Heritage Adviser to the British Pharmacological Society and gave the first  Paton Lecture to the BPS. She has published widely in the history of modern medical sciences and created numerous freely available resources in the field (http://www.histmodbiomed.org/ ),  with an extensive series of audio and video interviews that includes several pharmacologists http://www.histmodbiomed.org/article/drugs-and-pharmacologists.html 


Professor Sir Munir Pirmohamed 



Speaker: Sir Munir Pirmohammed, University of Liverpool

Biography: Professor Sir Munir Pirmohamed (MB ChB, PhD, FRCPE, FRCP, FFPM. FRSB, FBPhS, FMedSci) is David Weatherall Chair in Medicine at the University of Liverpool, NHS Chair of Pharmacogenetics, and a Consultant Physician at the Royal Liverpool University Hospital.  He is Director of the Centre for Drug Safety Sciences, and Director of the Wolfson Centre for Personalised Medicine.    He is also Director of HDR North. He is an inaugural NIHR Senior Investigator, Fellow of the Academy of Medical Sciences in the UK, Commissioner on Human Medicines.  He was President of British Pharmacological Society from January 2020-December 2021, and is currently President of the Association of Physicians.  He was awarded a Knights Bachelor in the Queen’s Birthday Honours in 2015. His research focuses on personalised medicine, clinical pharmacology and drug safety in a variety of disease areas, including cardiovascular medicine. 


Professor Adam Cohen 



Speaker: Prof Adam Cohen, professor of clinical pharmacology, Centre for Human Drug Research, Leiden, Netherlands

Talk title: History of BJCP 

Biography: Adam Cohen graduated in Pharmacy and Medicine from Leiden University. He worked at the department of Clinical Pharmacology of the Wellcome Research Laboratories in the UK in early development and larger trials in cardiovascular disease as project leader for one of the first biotech developments in Europe. He obtained a PhD degree from Leiden University (1986). He had a clinical attachment in internal medicine and nephrology in King’s College Hospital London.

Between 1987 and 2018 he was CEO of the Centre for Human Drug Research (CHDR), a research centre for early drug development and proof of concept studies in healthy subjects and patients. From 2018 he was Director of Innovation Services at CHDR and involved in advice and innovation. He is emeritus professor of Clinical Pharmacology at Leiden University Medical Centre and clinically attached to the department of nephrology and still actively involved in undergraduate and graduate education. He was vice-chairman of the Central Ethics Committee and the Competent Authority (CCMO) of the Netherlands between 1999 and 2011. He was Editor-in-Chief of the British Journal of Clinical Pharmacology until 2020. Adam has been non-executive board member of Omnicomm Inc(OMCM) in the USA until its acquisition and on the supervisory Board of the Rotterdam Eye Hospital. Since 2021 he advises biotech startups, venture capital investors and is active as an educator and publicist as well as a GP for Ukranian refugiees and an active amateur clarinettist.

Professor Ann Daly



Speaker: Professor Ann Daly, University of Newcastle

Talk title: BJCP and Personalised Medicine 

Biography: Ann Daly is Professor of Pharmacogenetics at the Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. She holds BA and PhD degrees in Biochemistry from the University of Dublin (Trinity College). She was a postdoc at the University of Geneva and then moved to Newcastle University where she was a founder member of the Newcastle Pharmacogenetics Research Group. Her current research is focused on the genetic susceptibility to idiosyncratic adverse drug reactions, pharmacogenetics of the human cytochromes P450 and the genomics of complex diseases, particularly liver disease. She has been a Senior Editor of the British Journal of Clinical Pharmacology since 2020. She has published over 250 peer reviewed articles and has a H-index of 101. 

Professor Catriona Waitt 




Speaker: Professor Catriona Waitt, University of Liverpool

Talk title: BJCP and Global Outreach

Biography: Catriona Waitt is a Professor of Clinical Pharmacology and Global Health at the University of Liverpool, UK, and is undertaking her Wellcome Clinical Research Career Development Fellow at the Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda. Her major interest is drug dosing and safety in populations who are complex and often neglected from clinical trials, particularly pregnant and breastfeeding mothers and their infants. Her fellowship “MILK: Maternal and Infant Lactation pharmacokinetics” explores the transfer of a range of anti-infective drugs from mother to breastfed infant, combining clinical studies and pharmacometric approaches. Alongside her research, she is a member of the Scientific Advisory Board of Pharmacometrics Africa and all her work has a strong capacity-building aspect.

Professor Geoffrey Tucker 



Speaker: Professor Geoffrey Tucker, University of Sheffield

Talk title: History of BJCP 

Biography: Emeritus Professor of Clinical Pharmacology and former Head of the Academic Unit of Clinical Pharmacology at the University of Sheffield, UK. Graduated in pharmacy (1964) with a Ph.D (1967) from the University of London (Chelsea College) and has an Honorary Doctorate (2009) from Uppsala University, Sweden. He was at the Virginia Mason Research Center (Seattle) and the Anesthesia Research Center, University of Washington from 1968-72.
His main research interests are pharmacokinetics, drug metabolism, pharmacogenetics, bioequivalence and the pharmacology of drugs used in anaesthesia. Author of over 400 scientific articles; rated in 2002 amongst the top 200 most cited pharmacologists worldwide by the Institute of Scientific Information.

Chairman of the Editorial Board of the British Journal of Clinical Pharmacology (1995-2002), Member of the Council of the British Pharmacological Society (1995-2002), of the Chemistry, Pharmacy and Standards Committee of the Committee on Safety of Medicines UK Medicines Commission (1990-1999), and of of the Expert Advisory Medicines Committee UK (2000- 2016). Expert Advisor to the European Medicines Agency (2008-2014), Council Member of the Clinical Division of The International Union of Pharmacology (1995-2005), Member (1995-8; 2005-18), Vice-President (2008-12) and Chairman of the Board of Pharmaceutical Sciences (2008-16) of the International Pharmaceutical Federation, Councillor (1988-91; 2004-2011), President-elect (2013-2015), President (2015-2017) and Honorary Member (2018-) of the International Society for the Study of Xenobiotics. Founding Member and Elder of the African Society for Drug Metabolism and Development (2007-), Member of the Senate of the European Federation of Pharmaceutical Sciences, , Fellow of the Royal College of Anaesthetists, and of the Royal College of Physicians of Edinburgh, Honorary Fellow of the Faculty of Pharmaceutical Medicine, Royal College of Physicians UK, of the British Pharmacological Society, of the British Toxicological Society, of the International Pharmaceutical Federation and of the American College of Clinical Pharmacology, Honorary Member of the Royal Pharmaceutical Society of Great Britain and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. The British Pharmacological Society Australasian Visitor (1987), the ASRA Lecturer (American Society of Regional Anesthesiology) (1991), Science Chairman of the British Pharmaceutical Society Conference (1995), the ESRA Lecturer (European Society of Regional Anaesthesia) (1997), Recipient of the GSK (1984) and Lilly (2000) Prizes of the British Pharmacological Society (2000). Visiting Professor at the Universities of Harvard (1981), Cincinnati (1983), Queensland (1981) and Otago (2000) and the US FDA Center of Drug Evaluation & Research (2001) and the ‘Candlelight Lecturer’ of the Swedish Academy of Pharmaceutical Sciences (2002). Recipient of the EUFEPS Award for Innovation in New, Faster, Safer Medicines (2004). Member of the organising committees of over 30 international conferences, and of the editorial boards of 15 journals (past and present).

Co-Founder and Chair (2000-12) of Simcyp Ltd, a University of Sheffield spin-out company that provides a platform for the prediction of pharmacokinetics/pharmacodynamics and the extent of drug-drug interactions with regard to demographics, ethnicity, genetics, formulation and disease. The company received the Queen’s Award for Innovation in Industry (2010) and was acquired by Certara In 2012.

Dr Jeffrey Aronson 



Speaker: Dr Jeffrey Aronson, University of Oxford

Talk title: History of BJCP 

Biography: Dr Jeffrey Aronson is a Physician and Clinical Pharmacologist working in the Centre for Evidence Based Medicine in the University of Oxford. He has written widely about all aspects of clinical pharmacology and about medical history, the philosophy of medicine, and medical language. He writes a weekly BMJ opinion column under the general title “When I Use a Word ….”. He was Editor-in-Chief of Meyler’s Side Effects of Drugs—The International Encyclopedia of Adverse Drug Reactions and Interactions (16th edition, 2015) and of its annual update volumes (Side Effects of Drugs Annuals 15–35). He chairs the British Pharmacopoeia Commission’s Expert Advisory Group on Pharmacy and Nomenclature and is a member of the WHO’s Expert Advisory Panel on International Pharmacopoeia and Pharmaceutical Preparations. He is President Emeritus, an Honorary Fellow, and immediate past Vice-President Publications of the British Pharmacological Society; an Honorary Fellow of the Faculty of Pharmaceutical Medicine of the Royal College of Physicians; and an Emeritus Fellow of Green-Templeton College, Oxford.

Professor James Dear 




Speaker: Professor James Dear, University of Edinburgh

Talk title: BJCP and Toxicology 

Biography: Professor James Dear is a Clinical Pharmacologist at the University of Edinburgh and a Consultant for the National Poisons Information Service. His overall objective is to make medicines safer for patients. He focuses specifically on developing novel point of care biomarkers for drug toxicity, which has great importance to both clinical patient care and commercial drug development. Paracetamol overdose is the leading cause of acute liver failure in the Western world. Professor Dear is developing novel treatments for those patients at high risk of liver failure, a group without effective treatments. This includes leading multi-centre trials of new first-in-class therapeutics and Advanced Therapies, such as cell therapy, to repair the injured liver.
 
 

Other speakers include: 

1). Dame June Raine, Medicines and Healthcare products Regulatory Agency
2).
3). Professor Serge Cremers, Columbia University New York
4). Professor James Ritter, Kings College London
5). Professor Geert Jan Groeneveld, Centre for Human Drug Research
6). Professor Robert Likic, University of Zagreb School of Medicine
7). Dr Andrew Webb, Kings College London
8). Professor Michael Rieder, Western University
9). Oscar Della Pasqua, GlaxoSmithKline
10). Dr Daniel Marks, AstraZeneca





 

Dr James Fullerton

 

Chair: A/Prof James Fullerton MA(Oxon) MBChB MRCP PhD FHEA

Biography: Dr James Fullerton is Associate Professor of Clinical Therapeutics in the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS) at the University of Oxford, and Honorary Consultant in Clinical Pharmacology and Acute General Medicine at the John Radcliffe (JR) Hospital. 

Dr Fullerton’s research focuses on the use of experimental medicine studies to promote scientific translation for patient benefit. He is an expert in the design, development and use of human immune challenge (HIC) models, employing these to explore fundamental biology, interrogate immune variance and unravel the interplay between disease and immune dysregulation. He has a particular interest in how HIC can be employed in translational/early clinical drug development to establish mechanistic proof-of-concept and tissue-based pharmacology of both established (enabling repurposing) and novel therapeutics, seeking to enable and catalyse the work of both academic and industrial partners. Clinically, he is interested in understanding the host immune response to inflammatory stimuli, most notably infection, and how this can inform decision making in the context of acute, unscheduled care episodes. 

He Chairs the JR Medicines Management and Therapeutics Committee, is Lead for Education in Clinical Pharmacology and Therapeutics at Oxford Medical School, Co-Lead for the Academic Specialised Foundation Programme (Thames Valley), an Honorary Clinical Lecturer at UCL, Executive Editor for the British Journal of Clinical Pharmacology and Supernumerary Fellow at St Hilda’s College. He is co-author of the leading textbook Rang and Dale’s Pharmacology.

Professor Robert Bies



Chair: Professor Robert Bies, Queen Mary University London

Biography: Dr. Bies is currently Professor of Pharmaceutical Sciences and Associate Dean of raduate Education  at the School of Pharmacy and Pharmaceutical Sciences as well as a member of the Institute for Artificial Intelligence and Data Science at the State University of New York at Buffalo. Prior to this, Dr. Bies was Associate Professor of Medicine and Medical and Molecular Genetics at the Indiana University School of Medicine and Director of the Disease and Therapeutic Response Modeling program for the Indiana Clinical Translational Sciences Institute. He serves as: project scientist at CAMH, University of Toronto; on the editorial boards of the Journal of Pharmacokinetics and Pharmacodynamics, Clinical Pharmacology and Therapeutics:Pharmacometrics and Systems Pharmacology, Journal of Clinical Pharmacology, Biopharmaceutics and Drug Disposition; and the British Journal of Clinical Pharmacology. Dr. Bies is a member of AAPS, ISoP, ACCP and ASCPT. He is also a Fellow of the International Society for Pharmacometrics.
.
Dr. Bies received a BSc degree in Pharmacy from the University of Toronto (1991), a Pharm.D. from the UTHSCSA and the University of Texas at Austin (1994) and a Ph.D. Pharmacology from Georgetown University in 1998. This was followed by postdoctoral training at the Center for Drug Development Sciences until 2000.

His research involves the application of pharmacometric approaches in HIV, opiate addiction, contraception, pregnancy, pediatrics, psychiatry, oncology and neurology as well as on novel methods development including machine learning approaches to model selection and optimization methods for parameter optimization in dynamic systems.

Professor Robert Flanagan



Chair: Professor Robert Flanagan, Kings College London 

Biography: RJ Flanagan PhD ERT MCSFS CChem FRSC FRCPath FRCPE HFCMHP Hon FFFLM
Professor Flanagan is Consultant Clinical Scientist in the Department of Precision Medicine, King’s College Hospital NHS Foundation Trust. He has some 50 years’ experience of clinical and forensic toxicology and is the author or co-author of more than 250 articles in scientific journals and 6 books. Particular interests have been treatment of mental illness especially schizophrenia, notably as regards the use of clozapine, and the diagnosis of substance misuse, especially misuse of volatiles such as butane. He regularly advises medical professionals, police, coroners, and prosecution and defence lawyers on toxicological issues. He has also acted as a consultant to the United Nations Office for Drugs and Crime and to the World Health Organization, most recently in Serbia/Kosovo, and also in the Middle East and in India. He is an assessor in forensic toxicology for the Netherlands Register of Court Experts and a Past-President of the British Academy of Forensic Sciences.
 


Chairs include: 

1). Professor Robin Ferner, University of Birmingham 
2). Professor Reecha Sofat, University of Liverpool 
3). Dr Emma Magavern, Queen Mary University London 


 

The John Vane Science Centre houses some of the research and education facilities for the Barts Cancer Institute and William Harvey Research Institute at Queen Mary University of London. These include the endocrinology lab and surgical skills lab enabling students to study with state-of-the-art Virtual Reality Surgical Simulators.

The nearest stations on the London Underground are Barbican and Farringdon on the Hammersmith and City, Metropolitan and Circle lines.

Transport for London publish interactive and downloadable maps showing Underground, Docklands Light Railway (DLR) and bus information.



John Vane Science Centre
Queen Mary University of London
Charterhouse Square
London
EC1M 6BQ

Tickets


General Registration Non-Member Ticket £15.00
General Registration Member Ticket £15.00
StR and Undergraduate Registration Non-Member Ticket Free
StR and Undergraduate Registration Member Ticket Free

We're excited to unveil our partnership opportunities! For more information on how to participate please contact our partnership manager on partnerships@bps.ac.uk

We thank the below partners for supporting this event.

         




From
23 April 2024
To
23 April 2024
Venue
John Vane Science Centre, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ




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