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Dosing in Animal Models of Neuroscience




The event will highlight some of the potential issues associated with current dosing practices and explore how to promote the adoption of more translationally relevant and ethically sound approaches.

There are widespread, systematic problems in how drug dosing is typically approached in preclinical blue-skies neuroscience. For example:
 
  • Historical dosing practices involving high doses that lack translational relevance.
  • Limited understanding and integration of pharmacokinetics (PK) in dose selection.
  • Routes of administration which can impact both animal welfare and the interpretability of results.
  • Current norms relying heavily on precedent rather than evidence.
  • These limitations compromise successful translatability of findings and raise ethical concerns.

Event Objectives:
 
  1. Raise awareness about the challenges of drug testing in preclinical neuroscience
  2. Encourage the neuroscience and pharmacology communities to challenge historical norms.
  3. Facilitate dialogue on next steps for the research community

Intended audience:

Neuroscientists and pharmacologists working in preclinical research in academia and industry
Whilst delegates of all career stages are welcome, content will be most suitable for those in postgraduate education or established research careers.

Intended Outcome for Delegates:

Participants will leave with: ​​​​​​
 
  • A mindset shift: from unquestioned replication of historical doses to intentional decision-making.
  • A clear understanding of the challenges and limitations of common dosing practices.
  • Motivation and knowledge to critically assess dose selection and route of administration in their own research.
  • Awareness of how dose selection and route of administration impacts both animal welfare and translational success.

Tuesday 23rd September 2025
Morning Session: Setting the Scene – Expert Perspectives
09:30 – 09:35 Welcome and Introduction
09:35 – 10:10 Overview of the issue and translational implications Dr Emma Robinson, University of Bristol
10:10 – 10:45 Pharmacokinetics Professor Amin Rostami-Hodjegan, University of Manchester
10:45 – 11:00 Refreshment Break
11:00 – 11:35 Dosing and Animal Welfare: Ethical Considerations and Scientific Impact Speaker TBC
11:35 – 12:00 Translational Gaps Professor Jonathan Cavanagh, University of Glasgow
12:00 – 12:35 Industry View: Lessons from translational pharmacology David Heal, DevelRx Ltd
12:35 – 13:00 Panel discussion and audience Q&A
13:00 – 13:45 Lunch Break
Afternoon Session: What’s the solution? Community Discussion & Next Steps
13:45 – 13:55 Welcome back and introduction to the afternoon session format
13:55 – 14:30 Breakout group 1
14:30 – 15:05 Breakout group 2
15:05 – 16:00 Whole group discussion of the breakout topics
16:00 – 16:15 Next steps and closing remarks
End of Programme

Dr Emma Robinson

Professor of Psychopharmacology, University of Bristol
 

Emma completed her BSc in Pharmacology in Bristol in 1995 and PhD in Psychopharmacology in 1999 supervised by Prof David Nutt, Dr Alan Hudson and Dr Helen Jackson.

She was awarded an RCUK Academic Fellowship, co-funded by the BPS Integrative Pharmacology Fund, which provided an opportunity to work at the University of Cambridge, Experimental Psychology Department with Profs Trevor Robbins and Jeffery Dalley.

Now based in Bristol’s School of Physiology, Pharmacology and Neuroscience, Emma’s research investigates the neural and neurochemical mediators of normal cognitive and emotional behaviour and their disruption in psychiatric disorders, particularly depression. Her work on novel rodent models for depression research has also provided an opportunity to undertake objective assessments of laboratory animal welfare.

Alongside research, Emma is involved in teaching across the science and professional programmes; development of online learning resources; and is actively involved in public engagement in science, including organising the Bristol Neuroscience Festival.


Professor Amin Rostami-Hodjegan

Professor of Systems Pharmacology and Director of Centre for Applied Pharmacokinetic Research, The University of Manchester

Professor Amin Rostami is an internationally recognised scientist and renowned thought leader in the area of translational modelling for drug development and precision dosing. He is recognised by many as a dynamic individual who has contributed to science education and business development equally. He has progressed through the ranks of Lecturer through Reader before becoming the first professor with the title of “Systems Pharmacology” in the world (University of Sheffield, 2007). In parallel, he has gathered his business and management acumen by serving on the board of directors of Simcyp (2002-2012) and the Certara Executive Team as Chief Scientific Officer (2014-current).

Professor Jonathan Cavanagh

University of Glasgow

Jonathan Cavanagh is Professor of Psychiatry at the University of Glasgow and an honorary consultant neuropsychiatrist at the Queen Elizabeth University Hospital.

He leads a group that is focused on exploring mechanisms underlying immune-mediated behaviours relevant to major psychiatric disorders using the techniques of molecular neuroimmunology.


David Heal

Executive Director and co-founder, DevelRx Ltd

David is an Executive Director and co-founder of DevelRx Ltd. DevelRx provides consultancy support to pharmaceutical companies developing novel CNS drugs. His initial training was as a neuroscientist and behavioural pharmacologist at the University of Oxford.

After a career in academic research, he joined the pharmaceutical industry with responsibility for CNS and metabolic drug research at Boots Pharmaceuticals and BASF Pharma. He co-founded and for 20 years was an Executive Director at the non-clinical CRO, RenaSci, before leaving to set up DevelRx. His experience in R&D encompasses the approval of 15 novel drugs for indications including ADHD, binge-eating disorder, schizophrenia, Parkinson’s disease, epilepsy, opiate withdrawal, opiate-induced adverse events, anaesthesia, haemodialysis-induced pruritis, and obesity.

He was awarded a DSc by Kings College, London University for his contribution to pharmacology research. He is a Visiting Professor at the University of Bath, a Fellow of the Royal Society of Chemistry and a member of the American College of Neuropsychopharmacology. He has authored more than 200 scientific articles and reviews, co-edited books and journal special issues on a range of clinical topics and serves on the editorial boards of several international scientific journals.


Registration for this event is available through the British Neuroscience Association website. Please use the link below to sign up! 

Register Here

From
23 September 2025
To
23 September 2025
Time
09:30 AM to 16:15 PM



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