New therapeutic modalities: Transforming receptor pharmacology




Registration open soon! 


Modulation of receptors and their intracellular signalling events continues to be a highly lucrative strategy for the discovery of novel therapeutics. However, the approaches used to modulate these targets have become much more varied in recent years. In this meeting we will discuss the new therapeutic modalities that are transforming our ability to pharmacologically modulate receptors and their intracellular signalling pathways.

 
                                                  Day 1 - Wednesday 2 April
09:45 – 10:15 Registration and Refreshments
10:15 – 10:30 Welcome and Introduction
 
Session 1 Novel Pharmacological Tools for GPCRs - Graham Ladds (University of Cambridge)
10:30 – 11:00 Applications of AI/ML to identify novel GLP-1R agonists
Dr Andrew Buchanan, AstraZeneca
11:00 – 11:30 Speaker TBC
11:30 – 11:45 OC1
11:45 – 12:00 OC2
12:00 – 12:30 Interdisciplinary approaches to understand GPCR signalling
Dr Abigail Pearce, Cambridge
12:30 – 13:00 Nanobodies at adhesion receptors: novel approaches for modulation
Dr Rolle Rahikainen, Tampere, Finland
 
13:00 – 14:00 Lunch and Poster Viewing
 
Session 2 New Approaches to Manipulate Intracellular Signalling - Laura Itzhaki (University of Cambridge)
14:00 – 14:30 Biologics approaches to targeted protein degradation
Dr James Hunt, AstraZeneca
14:30 – 15:00 Speaker TBC
15:00 – 15:15 OC 4
15:15 – 15:30 OC 5
15:30 – 15:50 Partner Session
 
15:50 – 16:20 Refreshment Break  
16:20 – 16:50 Signalling from internal membranes
Professor Miriam Stoeber, University of Geneva
16:50 – 17:05 OC 6
17:05 – 17:20 OC 7
17:20 – 17:50 Speaker TBC
17:50 – 17:55 Closing Remarks
 
                                                         Day 2 – Thursday 3rd April
08:45 – 09:10 Registration and refreshments
09:10 – 09:15 Welcome to day 2
 
Session 1 New modalities to modulate ion channels - Paul Miller (University of Cambridge)
09:15 – 09:45 Speaker TBC
09:45 – 10:15 Identified a new role for Elkin1 channel in touch sensation
Dr Sampurna Chakrabarti, Max-Delbrück-Centrum für Molekulare Medizin (MDC) – Berlin
10:15 – 10:30 OC 8
10:30 – 10:45 OC 9
10:45 – 11:05 Partner Session
 
11:05 – 11:35   Refreshment Break  
 
11:35 – 12:05 Epilepsy Gene Therapy Using an Engineered Potassium Channel. Also established an ion channel database of mutations and disease effects for predicting therapies for new patients identified with ion channel mutations
Professor Stephanie Schorge, Department of Neuro, Physiology & Pharmacology, UCL
12:05 – 12:20   OC 10
12:20 – 12:35   OC 11
12:35 – 13:05 Speaker TBC
13:05 – 13:30  Closing remarks and Prizes
Conference Close

From
02 April 2025
To
03 April 2025
Venue
St John's College, St John's Street, Cambridge

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